Mitigative Effect of Vitex Negundo against Fluoride induced Oxidative Stress Mediated Cardio and Nephrotoxicity

The present study investigated the mitigative effect of Vitex negundo against sodium fluoride (NaF) induced cardio and nephrotoxicity. hydroalcoholic extract leaves (HAEVNL) was prepared by maceration method. Group I, II, III served as normal, toxic, plant control groups in treatment schedule. IV V (200 400 mg/kg b.wt, p.o) groups. IV, treated with NaF (100ppm) through drinking water for 4 weeks. Cardiac kidney parameters such LDH, CK-MB, Lipid profile, Creatinine, Urea, Uric acid were estimated. heart tissues LPO, GSH, SOD, CAT levels histopathological studies performed. Phytochemical investigation showed alkaloids, saponins, phytosterols, flavonoids, phenols, tannins. Rats administered have demonstrated a significant rise TC, TG, LDL-C, VLDL-C, acid. Tissue LPO increased while there decrease serum HDL-C tissue levels. Treatment HAEVNL effective recovery NaF-induced evaluation also added to benefits leaves. concluded that leaf antioxidant fluoride- nephrotoxicity rats.